| Overview
This course presents a
rather intense introduction to the major principles of agitator process design,
as applied to liquid and gas-liquid systems as commonly found in the
Bioprocessing and Pharmaceutical industries. A brief introduction is given to
the basics of agitation theory as applicable, but the emphasis is on practical
application of theory, rather than as an academic treatise. Specific guidelines
are given for major industry applications, and sanitary aspects are covered as
well. Several chapters are devoted entirely to aerobic fermentation design and
scale-up, as this is an area which has been most neglected in courses of this
kind.
The student must take a multiple-choice quiz consisting of forty (40) questions
at the end of the course to obtain PDH credits.
Who
Should Take This Course?
This is a course for
people who must specify, operate, purchase or optimize fluid agitation equipment
used for Bioprocessing and Pharmaceutical applications. Such applications
include, for example, simple tanks containing CIP solutions, broth and slurry
tanks, compounding tanks and fermenters/bioreactors. The application technology
ranges from simple to complex, and the construction methods range from standard
to highly sanitary. A basic Introduction to general agitator design principles
is given, but the focus is specifically on applications found in the
Pharmaceutical Bioprocessing Industries.
Having a working knowledge
of the terminology and technology used by agitator designers enables the
attendee to assume a more active role in the purchase and operation of such
equipment, instead of leaving everything in the hands of the vendors. The result
can be a lower price paid by specifying clearly what is needed, while avoiding
undersized equipment that can cause lost productivity. In the case of fermenters,
proper information can even be essential to assure the right product is capable
of being made, and that energy costs are minimized. Senior management can see
how the agitator design can impact overall production and profit.
Specific Knowledge
or Skill Obtained
This course teaches the
following specific knowledge and skills:
- Be
able to choose the right impellers for the job
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Understand how power and pumping are calculated
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Understand the basics of gas dispersion
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Understand the basics of heat transfer
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Understand sanitary design options
-
Understand the merits of various seal configurations
-
Gain a familiarity with bioprocessing sizing guidelines
-
Learn the promise and limitations of scale-up
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Understand what data are needed to design aerobic fermenters
- Be
able to design a pilot fermentation protocol that will provide such data
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Learn how to scale-up fermenters
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Learn how to minimize power consumption in fermenters.
-
Understand the merits of various impeller types
-
Understand the unique issues of cell culture bioreactors
-
View a fermenter as a dynamic system
-
Understand how CFD can aid in system analysis
Course
Click on the following
link to the PDF document to review the course material before taking the
quiz for credit.
Agitator
Design Principles
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To receive PDH
credit for this course, you must pass a multiple-choice quiz.
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