Agitator Design Principals: Pharmaceutical and Biotechnology Applications

In Agitator Design Principals: Pharmaceutical and Biotechnology Applications, you'll learn ...

• Be able to choose the right impellers for the job
• Understand how power and pumping are calculated
• Understand the basics of gas dispersion
• Understand the basics of heat transfer

Overview

Preview a portion of this course before purchasing it.

Credit: 8 PDH

Length: 125 pages

This course presents a rather intense introduction to the major principles of agitator process design, as applied to liquid and gas-liquid systems as commonly found in the Bioprocessing and Pharmaceutical industries. A brief introduction is given to the basics of agitation theory as applicable, but the emphasis is on practical application of theory, rather than as an academic treatise. Specific guidelines are given for major industry applications, and sanitary aspects are covered as well. Several chapters are devoted entirely to aerobic fermentation design and scale-up, as this is an area which has been most neglected in courses of this kind.

This course is helpful for people who must specify, operate, purchase or optimize fluid agitation equipment used for Bioprocessing and Pharmaceutical applications. Such applications include, for example, simple tanks containing CIP solutions, broth and slurry tanks, compounding tanks and fermenters/bioreactors. The application technology ranges from simple to complex, and the construction methods range from standard to highly sanitary. A basic Introduction to general agitator design principles is given, but the focus is specifically on applications found in the Pharmaceutical Bioprocessing Industries.

Having a working knowledge of the terminology and technology used by agitator designers enables the attendee to assume a more active role in the purchase and operation of such equipment, instead of leaving everything in the hands of the vendors. The result can be a lower price paid by specifying clearly what is needed, while avoiding undersized equipment that can cause lost productivity. In the case of fermenters, proper information can even be essential to assure the right product is capable of being made, and that energy costs are minimized. Senior management can see how the agitator design can impact overall production and profit.

Specific Knowledge or Skill Obtained

This course teaches the following specific knowledge and skills:

• Be able to choose the right impellers for the job
• Understand how power and pumping are calculated
• Understand the basics of gas dispersion
• Understand the basics of heat transfer
• Understand sanitary design options
• Understand the merits of various seal configurations
• Gain a familiarity with bioprocessing sizing guidelines
• Learn the promise and limitations of scale-up
• Understand what data are needed to design aerobic fermenters
• Be able to design a pilot fermentation protocol that will provide such data
• Learn how to scale-up fermenters
• Learn how to minimize power consumption in fermenters
• Understand the merits of various impeller types
• Understand the unique issues of cell culture bioreactors
• View a fermenter as a dynamic system
• Understand how CFD can aid in system analysis

Certificate of Completion

You will be able to immediately print a certificate of completion after passing a multiple-choice quiz consisting of 52 questions. PDH credits are not awarded until the course is completed and quiz is passed.